1) Do not use onmouseover for important actions
2) You may use onmouseover for:
a) convenience, to to things faster - ALWAYS provide an intuitive click alternative however!
b) For 'nice-to-have' - eg context help, highlighting etc -
3) MAXIMIZE the click-able areas! - so, do not just add a link to a word, but to the full text - or even to the container (div, span, td) containing the text -
4) Early test your apps on touchscreen devices: single, as well as multi-touch!